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Zyban Tablet


Zyban Tablet

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Zyban (bupropion) is an antidepressant in the aminoketone drug class used for smoking cessation. A generic formulation is available. The most common side effects of Zyban are agitation, dry mouth, insomnia, headache, nausea, constipation, and tremor. Some patients may experience weight loss. Seizures also occur, especially at higher doses.

The usual dose of Zyban is 150 to 450 mg daily. Zyban should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Monamine oxidase inhibitors (MAOI) should not be combined with Zyban because of the risk of severe reactions. At least 14 days should elapse between discontinuation of an MAOI and initiation of Zyban (bupropion).

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Product Description


Active Indredients

Zyban tablets contain the active ingredient bupropion hydrochloride, which is a medicine used to help people who are addicted to nicotine to give up smoking. It acts in the brain but is not the same as nicotine replacement therapy.

How to take this Medicine?

The usual recommended dose is 50 mg taken as needed, approximately 30 to 60 minutes before sexual activity. However, the medication may be taken any time from 4 hours to half an hour before sexual activity. Based on the effectiveness and side effects of the medication, the dose may be increased to 100 mg or decreased to 25 mg.

The maximum recommended dose is 100 mg and it is not recommended to take more than one dose per day. Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

How does it work?

It is not fully understood how this medicine works to help people give up smoking, but it is known that bupropion affects neurotransmitters in the brain. Neurotransmitters are chemicals that are stored in nerve cells and are involved in transmitting messages between the nerve cells.

Neurotransmitters are released from nerve cells as a message is transmitted. Once the message has been transmitted, the nerve cells then reabsorb the neurotransmitter.

Bupropion prevents two of these neurotransmitters, noradrenaline and dopamine, from being reabsorbed back into the nerve cells in the brain. Noradrenaline and dopamine are responsible for moderating mood and various other processes in the brain. It is thought that bupropion helps people to quit smoking by increasing the amount of noradrenaline and dopamine free to act in the brain.

Bupropion is used in combination with motivational support techniques. You should seek help and support as much as possible while giving up smoking, even while taking this medicine, as this will increase your chance of success.

How to take Zyban Tablets?

You should start taking this medicine while you are still smoking and set a 'target stop date' for within the first two weeks of treatment, preferably in the second week. This is because the medicine needs time to start working.

Zyban tablets can be taken either with or without food. They should be swallowed whole with a drink of water - do not chew, crush or break them. The tablets are 'prolonged release' tablets, which means they release the medicine gradually over a few hours after you take them. If you chew, crush or break the tablets this causes all the medicine to be released at once, which increases the chance of getting side effects.

The usual dose is one tablet once a day for the first six days, increasing on day seven to one tablet twice a day. (Elderly people, those with any kidney or liver problems and people with a higher risk of fits (see below) may be advised to continue taking the medicine once a day and not increase to twice a day. Follow the instructions given by your doctor.)

There should be an interval of at least eight hours between your doses. When you are taking the medicine twice a day it is best to take your first dose when you get up in the morning and your second dose at least eight hours later. Try to avoid taking your second dose at bedtime, as difficulty sleeping (insomnia) is a very common side effect of the medicine.

If you forget to take a dose just leave out the missed dose and take your next dose as usual at your usual time. Don't take a double dose to make up for a missed dose.

If you have not managed to stop smoking by the seventh week of treatment, your doctor will ask you to stop taking this medicine. If you have stopped smoking you can continue treatment for a total of nine weeks and after this you should stop taking Zyban. Your doctor may suggest you stop taking it gradually; follow the instructions given by your doctor.

Precautions And Safety Warnings/ Overdose

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The safety of this medicine for use during pregnancy has not been established. It should not be used by pregnant women.

Ask your doctor, pharmacist or midwife for advice on giving up smoking if you are pregnant. Continuing to smoke during pregnancy has many harmful effects on your baby.

This medicine passes into breast milk. Mothers who are breastfeeding should not take this medicine. However, continuing to smoke is very harmful to your baby and you should get advice from your doctor, pharmacist, midwife or health visitor on how to give up smoking while you are breastfeeding.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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