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Altrace/Ramipril Tablet

 

Altrace Tablet

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Altrace/Ramipril is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Ramipril is also used to improve survival after a heart attack. It may also be used in high risk patients (such as patients with heart disease/diabetes) to help prevent heart attacks and strokes. This medication may also be used to treat heart failure in patients who have had a recent heart attack.

Ramipril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This medication may also be used to help protect the kidneys from harm due to diabetes.

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Product Description

 

Active Indredients

Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°C and 112°C.

The CAS Registry Number is 87333-19-5. Ramipril’s chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octa hydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester; its structural formula is:

ADALAT® CC (nifedipine) Structural Formula Illustration

Its empiric formula is C23H32N2O5, and its molecular weight is 416.5.

Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl angiotensin converting enzyme inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.

How to take this Medicine?

Always take Ramipril tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Take this medicine by mouth at the same time of the day each day. Swallow the tablets with liquid.
Doses:
Treatment of high blood pressure
The usual starting dose is 1.25 mg or 2.5 mg once daily. Your doctor will adjust the amount you take until your blood pressure is controlled. The maximum dose is 10 mg once daily. If you are already taking diuretics (water tablets), your doctor may stop or reduce the amount of the diuretic you take before beginning treatment with Ramipril tablets.

Treatment to reduce or delay the worsening of kidney problems

You may be started on a dose of 1.25 mg or 2.5 mg once daily. Your doctor will adjust the amount you are taking. The usual dose is 5 mg or 10 mg once daily.
Treatment of heart failure
The usual starting dose is 1.25 mg once daily. Your doctor will adjust the amount you take. The maximum dose is 10 mg daily. Two administrations per day are preferable.
Treatment after you have had a heart attack
The usual starting dose is 1.25 mg once daily to 2.5 mg twice daily. Your doctor will adjust the amount you take. The usual dose is 10 mg daily. Two administrations per day are preferable.

Elderly
Your doctor will reduce the initial dose and adjust your treatment more slowly.

What are the possible side effects of ramipril (Altace)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking ramipril and call your doctor at once if you have a serious side effect such as:
feeling like you might pass out;
high potassium level (slow heart rate, weak pulse, muscle weakness, tingly feeling;
dry mouth, thirst, confusion, swelling, and urinating less than usual or not at all;
pale skin, dark colored urine, easy bruising or bleeding;
jaundice...

Possible side effects

Like all medicines, Ramipril tablets can cause side effects, although not everybody gets them.

Stop taking Ramipril tablets and contact your doctor immediately, if you notice any of the following serious side effects - you may need urgent medical treatment:
Swelling of the face, lips or throat which make it difficult to swallow or breathe, as well as itching and rashes. This could be a sign of a severe allergic reaction to Ramipril tablets.
Severe skin reactions including rash, ulcers in your mouth, worsening of a pre-existing skin disease, reddening, blistering or detachment of skin (such as Stevens-Johnson syndrome, toxic epidermal necrolysis or erythema multiforme).

Contact your doctor immediately, if you notice any of the following:
Faster heart rate, uneven or forceful heartbeat (palpitations), chest pain, tightness in your chest or more serious
problems including heart attack and stroke
Shortness of breath or a cough. These could be signs of lung problems
Bruising more easily, bleeding for longer than normal, any sign of bleeding (e.g. bleeding from the gums), purplespots blotching on the skin or getting infections more easily than usual, sore throat and fever, feeling tired, faint, dizzy or having pale skin. These can be signs of blood or bone marrow problems
Severe stomach pain which may reach through to your back. This could be a sign of pancreatitis (inflammation of the pancreas).
Fever, chills, tiredness, loss of appetite, stomach pain, feeling sick, yellowing of your skin or eyes (jaundice). These can be signs of liver problems such as hepatitis (inflammation of the liver) or liver damage.

Precautions And Safety Warnings/ Overdose

Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

Declaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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